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The subjects you will take in your first 2 or 3 semesters at college/university will mainly consist of general chemistry, biology, and physics. Though these classes are not hard conceptually, they do require a lot of studying and doing homework.
From sophomore year and on, the classes you take are more concentrated towards your major. For example, if you are a chemistry major, you will take all the general sciences your first year, then organic chemistry I & II , physical chemistry I & II, inorganic chemistry, analytical chemistry, and etc. These classes come with labs, so they are all time intensive. All the majors in the science and engineering area are like this including computer science.
If you're very math and science oriented, then you will have an easier time your first couple semesters, but the classes and the concepts do get very hard. I attend UT Austin, and I think the upper level courses are challenging. If you're willing to put in the work and hours, then you should be fine.