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It can get to you, but it depends on whether you have the personality to take work home. Also there are different types of settings (from subacute units in hospitals to outpatient clinics) and different ages and diagnosis to consider. Some colleagues who did one of their internships in a burn unit said this was an emotionally draining experience.
I would recommend that you do volunteer work before you apply to an occupational therapy program. Volunteer in a setting that has an occupational therapist on site and in a setting that you think may be of interest to you - outpatient clinics, hospitals, public schools, etc. you will probably just observe, but you will get an idea if this is the profession for you, plus it will look good on your admission application!