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There are several reasons why pharmaceutical sales can be stressful. It is a highly regulated industry and compliance with regulations are very important. Access to doctors offices has become more and more restricted over the years. The other stressors can include underperforming against sales goals, and an overbearing sales manager, but these can be true for any industry. To be fair balanced, there are many reasons why it's not a stressful career. Typically you set your own schedule, you may have a great manager, and if you perform well it can be very rewarding. There are many medications that make huge differences in people's lives, and educating people about them can be very fulfilling.