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Do you mean you don't want to interact directly with the public or you don't want to work directly with anyone at all?
Engineering and certain types of computer science, especially dealing with graphics and 3D visualization might fit the bill. Many science fields need people who can do data visualization. There are a lot of fields that are hard to get exposure to as a student. For example, you could become an expert at AutoCAD or ArcGIS, or you could become an app developer, or a website designer. There are many extremely technical design jobs out that that your average creative person would not be able to handle. Take as much math, science, and programming as possible and maybe throw in some graphic design classes.
With most highly technical careers, you will not be the only not-so-social person, but make sure you practice so you can get through interviews and dealing with managers and coworkers civilly. Eventually, you might be able to work from home, but probably not just starting out unless you can start you own web-based business while in school.
Sheila Von Mayer
Statistics if you like math, organizational development if you want to go into business, website development or any IT position usually will leave you to yourself at a desk. Depends on what you like other than to work alone.